CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogenesis

CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogenesis

CD47 is a transmembrane protein that functions as a receptor for thrombospondin-1 (TSP1) and a ligand for inhibitory receptor signal-regulatory protein-α (SIRPα). Blocking the interaction between CD47 on tumor cells and SIRPα on macrophages has been shown to induce antitumor responses. Here we investigated the role of CD47 expression in tumor stroma in tumorigenesis by comparing tumor growth in...

Trp53 inactivation in the tumor microenvironment promotes tumor progression by enhancing pro-inflammatory tumor stromal populations

Inactivation of the tumor suppressor p53 is one of the leading causes of cancer as p53 inactivation via somatic mutations occurs in 50% of human cancers and sometimes in fibroblasts within the tumor microenvironment (TME). Recent studies by our laboratory and others suggest that p53 inactivation promotes a pro-inflammatory host microenvironment elevated serum inflammatory cytokines/ chemokines,...

Accumulation and Angiogenesis Growth by Enhancing Myeloid Cell Tumor-Derived IL-35 Promotes Tumor

Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression.

Neuropilin-1 (NRP1) is a VEGF(165) and semaphorin receptor expressed by vascular endothelial cells (EC) and tumor cells. The function of NRP1 in tumor cells is unknown. NRP1 was overexpressed in Dunning rat prostate carcinoma AT2.1 cells using a tetracycline-inducible promoter. Concomitant with increased NRP1 expression in response to a tetracycline homologue, doxycycline (Dox), basal cell moti...

Morphine Promotes Tumor Angiogenesis and Increases Breast Cancer Progression

Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and in vivo studies showed that morphine also modulates angiogenesis and regulates tumour cell growth. Unfortunately, the results obtained by these studies are still contradictory. In order to better dissect the role of morphine in cancer cell growth and angiogenesis we per...